WHAT ARE SPMS?

SPMs, which stands for Specialized Pro-Resolving Mediators, are a family of bioactive lipids that we synthesize in our bodies from omega-3 EPA and DHA, and that promote the resolution of the inflammatory response.

Unlike traditional anti-inflammatory agents, SPMs do not suppress the inflammatory response, but rather actively regulate it, promoting its natural physiological resolution without compromising the immune system.

SPMs comprise several subfamilies, including resolvins (E and D series), protectins, maresins, and lipoxins, as well as their precursors, 17-HDHA, 14-HDHA, and 18-HEPE. These molecules exert specific functions on immune cells such as neutrophils, macrophages, and lymphocytes, facilitating the termination of the inflammatory process: arresting leukocyte migration, eliminating cellular debris (efferocytosis), restoring tissue homeostasis, and regenerating tissue.

Given the recent identification of these SPMs and their known mechanism of action, SPMs represent an emerging therapeutic paradigm in the management of inflammation in different conditions, including athletes.